måndag 12 augusti 2013

Blogpost 20130813 - Music 1308


Blogpost 20130813 - Music1308

Adds some fun music
My style is mostly to club, Swedish hip hop and rock as Linkin Park.
But here I put out such from Album which I think is good and go and listen to over and over again.
Thus no particular style of music. Some of the artists are new or not so well known. I listen a lot to music, and always waiting for something as a new good album.


Lägger in lite kul musik
Min stil ligger mest åt club, svensk hiphop och rock som Linkin Park.
Men här lägger jag ut sådant från Album som jag tycker är bra och går och lyssna på om och om igen.
Alltså ingen speciell musikstil. En del av artisterna är nya eller inte så välkända. Jag lyssnar mycket på musik, och väntar ständigt på nått nytt bra Album.

Album

Modern Life is War - Fever Hunting
Media Cunt
Blind Are Breeding

Selina Gomez - Stars Dance
Stars Dance
Forget Forever
Save The Day
B.E.A.T.
Undercover
Love Will Remember

Annie - The A&R EP
Ralph Macchio
Invisible
Mixed Emotions
Hold On

Moderat - II
Bad Kingdom

Single

The Weekend - Love In The Sky
Love In The Sky (Explicit Version)

Martin Garrix - Animals
Animals (Original Mix)

The Naked And Famous - Hearts Like Ours
Hearts Like Ours

The Preatures - Is This How U Feel?
Is This How U Feel? (Classixx Remix)

Basecamp - Emmanuel
Emmanuel

Friends - The Way
The Way

Miguel feat. Jessie Ware - Adorn
Adorn

söndag 11 augusti 2013

Supercapacitor could shrink size of mobile electronics


http://www.theengineer.co.uk/channels/design-engineering/news/supercapacitor-could-shrink-size-of-mobile-electronics/1016892.article

Supercapacitor could shrink size of mobile electronics

Scientists have created a supercapacitor that could help electronics designer create mobile phones and cameras that are smaller, lighter and thinner than currently possible.
The power supply measures less than half a centimetre across and is made from a flexible material, opening up the possibility for wearable electronics. The research is published in the Royal Society of Chemistry journal Energy & Environmental Science.
Reducing the size of portable electronic devices requires power supplies to be shrunk along with an increase in the flexibility of power supplies in electronic circuits. Supercapacitors are attractive power supplies because they can store almost as much energy as a battery, with the advantage of high-speed energy discharge. Supercapacitor electrodes are normally made from carbon or conducting polymers, but these can be relatively costly.
A team led by Prof Oliver G Schmidt at the Leibniz Institute for Solid State and Materials Research in Dresden (IFW-Dresden) examined the use of manganese dioxide as an alternative electrode material, which is less expensive than the standard materials.
Manganese dioxide is not very electrically conductive, nor is it naturally flexible or strong. However, the scientists overcame this by vaporising the manganese dioxide using an electron beam and then allowing the gaseous atoms to precipitate into thin, bendy films. They incorporated very thin layers of gold into the films to improve the electrical conductivity of the material.
Tests on the new micro-supercapacitor showed that the tiny, bendy power supply can store more energy and provide more power per unit volume than supercapacitors available today.
In a statement, Dr Chenglin Yan, leader of the research group at IFW-Dresden, said, ‘Supercapacitors, as a new class of energy device, can store high energy and provide high power, bridging the gap between rechargeable batteries and conventional capacitors. So we thought a micro-supercapacitor would be an important development in the rapid advance of portable consumer electronics, which need small lightweight, flexible micro-scale power sources.
‘The device could be applied to many miniaturised technologies, including implantable medical devices and active radio frequency identification (RFID) tags for self-powered miniaturised devices.’
The next step in the team’s research is finding a cheaper alternative to gold to improve the conductivity of the micro-supercapacitor.


fredag 9 augusti 2013

Cinema Releases 2013-08-10


Movies I've seen at the cinema or think is interesting to see ...

Filmer jag sett på bio eller tycker verkar intressanta att se...

20130821 Percy Jackson - Sea of Monsters - 20th Century Fox
               Official - www.percyjacksonthemovie.com‎
20130823 Mortal Instrument - City of Bones  - Constantin Film, Unique Features (TMI) inc. 
               Official - http://www.themortalinstrumentsmovie.com

tisdag 6 augusti 2013

ETHERSPHERE


http://www.seas.upenn.edu/~gaj1/ethergg.html

ETHERSPHERE

BY

GEORGE GILDER

New low earth orbit satellites mark as decisive
a break in the history of space-based communications
as the PC represented in the history of computing.
Pay attention to much-maligned Teledesic.  Backed
by Craig McCaw and Bill Gates, it is the only LEO
fully focused on serving computers.



"They'll Be Crowding The Skies."



     THUS STEVEN DORFMAN, president of telecommunications and
space operations for GM Hughes_the colossus of the satellite
industry_warned the world of a new peril in the skies.  Planning
to launch 840 satellites in low earth orbits, at an altitude of
some 435 miles, were a gang of cellular phone jocks and computer
hackers from Seattle going under the name of Teledesic.  Led
by Craig McCaw and Bill Gates, they were barging onto his turf
and threatening to ruin the neighborhood.

     You get the image of the heavens darkening and a new Ice Age
looming as more and more of this low-orbit junk_including a total
of some 1,200 satellites from Motorola's Iridium, Loral-Qualcomm's
Globalstar and Teledesic, among other LEO projects_accumulates in
the skies.  Ultimately, from this point of view, you might imagine
the clutter of LEOs eclipsing the geostationary orbit itself, the
so-called Clarke belt, some 21,000 miles farther out.  Named after
science-fiction guru Arthur C. Clarke, the geostationary orbit is
the girdle and firmament of the Hughes empire.

     In an article in Wireless magazine in 1945, Clarke first
predicted that satellites in orbit 22,282 miles (35,860 kilometers)
above the equator, where the period of revolution is 24 hours, could
maintain a constant elevation and angle from any point on Earth.  In
such a fixed orbit, a device could remain for decades, receiving signals
from a transmitter on the earth and radiating them back across
continents.

     The Clarke orbit also posed a problem, however_the reverse
square law for signal power.  Signals in space attenuate in
proportion to the square of the distance they travel.  This means
that communications with satellites 22,000 miles away typically
require large antenna dishes (as much as 10 meters wide) or
megawatts of focused beam power.

     Now, however, a new satellite industry is emerging, based on
gains in computer and microchip technology.  These advances allow
the use of compact handsets with small smart antennas that can
track low earth orbit satellites sweeping across the skies at a
speed of 25,000 kilometers an hour at a variety of altitudes
between 500 and 1,400 kilometers above the earth.  Roughly 60
times nearer than geostationary satellites, LEOs find the inverse
square law working in their favor, allowing them to offer far
more capacity, cheaper and smaller antennas, or some combination
of both.  Breaking out of the Clarke orbit, these systems vastly
expand the total available room for space-based communications
gear.

     It is indeed possible to "crowd" the Clarke belt_a
relatively narrow swath at a single altitude directly above the
equator.  But even this swath does not become physically
congested; collisions are no problem.  The Clarke belt becomes
crowded because the ability of antennas on the ground to
discriminate among satellites is limited by the size of the
antenna.  Spaceway and Teledesic both plan to use the Ka band of
frequencies, between 17 gigahertz and 30 gigahertz, or billions
of cycles per second.  In this band, reasonably sized antennas 66
centimeters wide can distinguish between geostationary satellites
two degrees apart.  That's some 800 miles in the Clarke belt.
Thus no physical crowding.  But it means that there are only a
total of 180 Clarke slots for Ka band devices, including
undesirable space over oceans.

     LEOs, however, can be launched anywhere between the earth's
atmosphere and a layer of intense radiation called the Van Allen
Belt.  The very concept of crowding becomes absurd in this 900
kilometer span of elevations for moving orbits that can be 500
meters apart or less.  Thus the 21 proposed orbital planes of
Teledesic occupy a total of 10 kilometers of altitude.  At this
rate, 70 or more Teledesic systems, comprising some 65,000
satellites, could comfortably fit in low earth orbits.

     Nonetheless, it was clear that the LEOs, one way or another,
were crowding Hughes.  Hughes commands satellite systems or
projects that compete with every one of the LEOs.  Hughes
responded to the threat of Teledesic by announcing the expansion
of its Spaceway satellite system, then planned for North America
alone, to cover the entire globe.  Then, invoking the absolute
priority currently granted geostationary systems, Hughes asked
the Federal Communications Commission to block Teledesic entirely
by assigning Spaceway the full five gigahertz of spectrum
internationally available in the Ka band.

     On May 27, Dorfman summoned the upstarts, Craig McCaw and
Teledesic President Russell Daggatt, to Hughes headquarters in
Los Angeles for a talk.  Busy with Microsoft_the Redmond, Wash.,
company that in 1993 temporarily surpassed the market value of
General Motors_Teledesic partner Bill Gates did not make the
trip.  But as the epitome of the personal computer industry, his
presence haunted the scene.

     Together with Spaceway chief Kevin McGrath, Dorfman set out
to convince the Seattle venturers to give up their foolhardy
scheme and instead join with Hughes in the nine satellites of
Spaceway.  Not only could Spaceway's nine satellites cover the
entire globe with the same services that Teledesic's 840
satellites would provide, Spaceway could be expanded
incrementally as demand emerged.  Just loft another Hughes
satellite.  Indeed, Spaceway's ultimate system envisaged 17
satellites.  With "every component proprietary to Hughes," as
Dorfman said, the satellites only cost some $ 150 million apiece.
By contrast, most of the $ 9 billion Teledesic system would have
to be launched before global services could begin.

     Nonetheless, the new LEOs marked as decisive a break in the
history of space-based communications as the PC represented in
the history of computing.  Moreover, Teledesic would be the only
LEO fully focused on serving computers_the first truly "global
Internet," as McCaw's vice president Tom Alberg depicted it.  It
brings space communications at last into the age of ubiquitous
microchip intelligence, and it brings the law of the microcosm
into space communications.

     If you enjoyed the New World of Wireless on the ground with
its fierce battles between communications standards, technical
geniuses, giant companies, impetuous entrepreneurs and industrial
politicians on three continents_you will relish the reprise
hundreds and even thousands of miles up.  Launching Teledesic,
McCaw and Gates were extending bandwidth abundance from earth
into space.  Observers, however, often did not like what they
heard.

Bad Press For Two Billionaires
     Every so often, the media is taken by the notion of
technology as a morality tale.  In place of a gripping saga of
unjustly obscure geniuses enriching the world by their heroic
creativity in the teeth of uncomprehending bureaucrats and
politicians, the media treat technology ventures as a school for
scandal.  We have mock exposes of computer hype, monopoly,
vaporware, viruses, infoscams, netporn, securities "fraud" and
deviously undocumented software calls.  Pundits gabble endlessly
about the gap yawning between the information rich and the
information poor, thus consigning themselves undeniably, amid
many yawns, to the latter category.  While American market share
climbs near 70% in computers, networks, software and leading-edge
semiconductors, analysts furrow the brows of the Atlantic Monthly
with tales of farseeing foreign teams, spearheaded by visionary
government officials, capturing the markets of American cowboy
capitalists.  They spiel implausible yams of tough-minded trade
warriors prying open the jaws of Japan for Toys "R" Us, closing
down vicious Korean vendors of low-priced dynamic RAMs, or
blasting through barriers to U.S. telecom gear in the Tokyo-Osaka
corridor, saving the day for Motorola's soon-to-be cobwebbed
factories for analog cellular phones.

     One of these sagas began early this year with two Seattle
billionaires, McCaw and Gates, allegedly boarding McCaw's sleek
yacht and going on an ego trip.  With McCaw pitching in an early
nickel, and the boat, and Gates hoisting his name as a sail, the
two tycoons seemed to sweep away from the shores of rationality,
as the media told it, into a sea of microwaves and arsenic.
Spinning out Teledesic to build an information superhighway in
the sky, they proposed to strew the heavens with 840 satellites,
plus 84 spares.  All would whirl around the world at a height of
700 kilometers (435 miles), using what they told the FCC would be
some 500 million gallium arsenide microchips to issue frequencies
between 20 and 60 gigahertz from some 180,000 phased-array
antennas.  The entire project seemed suffused with gigahertz and
gigabucks.  "We're bandwidth bulls," says Teledesic President
Daggatt.

     In case the hype of the sponsors failed to keep the system
radiant and aloft, fueling it also would be a total of 12,000
batteries fed by thin film solar collectors stretching out behind
the satellite "birds" in some 130 square kilometers of gossamer
wings.  Working at 4% efficiency, these cells would collectively
generate 10 megawatts of power, enough to light a small city,
but, so the critics said, insufficient to reach Seattle at
microwave frequencies in the rain.  (The Teledesic frequencies
are readily absorbed by water in the air).  To manage the
elaborate mesh of fast-packet communications among the satellites
and ground terminals, the constellation would bear some 282,000
Mips, or millions of instructions per second, of radiation-hard
microprocessors and a trillion bytes or so of rad-hard RAM.  In
effect, Teledesic would be launching into space one of the
world's largest and most expensive massively parallel computer
systems.

     At a mere $ 9 billion, to be put up by interested investors,
Teledesic's lawyers told the FCC, the price would be a bargain
for the U.S. and the world.  (By contrast, current plans call for
$ 15 billion just to lay fiber for interactive TV in California).
But former Motorola, now Kodak, chief George Fisher fresh from
pondering numbers for the apparently similar Iridium
projects_suggested that $ 40 billion for Teledesic would be more
like it.  (Teledesic had the improbable result of making
Iridium's 66-satellite plan, greeted in 1990 with much of the
scorn now lavished on Teledesic, seem modest).  Just rocketing
the 840 satellites into orbit was said to entail a successful
launch every week for a year and a half at a time when hoisting
satellites is still a precarious and sometime thing.

     Even if Teledesic succeeded in getting the things up, so
other scientists suggested, the satellites would then be impaled
on some 7,000 pieces of space debris in the chosen orbits.  In
any case, so it was widely reported, 10% would fail every year,
some tumbling out of orbit, others joining the whirl of litter,
where they would fly ready to impale the remainder of the
satellites and the remnants of the two billionaires'
reputations.

     Surely these sages know that by the year 2001, when the
systems would be up and running, the world will be swimming in
the bandwidth of "information superhighways."  Why support this
lavish launch of technology for a communications system that
would be dwarfed by capabilities already demonstrated on the
ground?

     Summing up a near-consensus of critics, John Pike, director
of the Federation of American Scientists' Space Policy Project,
declared to the Wall Street Journal, "God save us.  It's the
stupidest thing I've ever heard of!" Provoking Pike may have been
the origins of the multisatellite architecture in the Star Wars
"brilliant pebbles" program.  Teledesic's most amazing
achievement to date has been to displace the Strategic Defense
Initiative as Pike's peak example of stupidity.

     While McCaw and Gates could be dismissed as tyros in the
satellite field, Hughes is world champion.  Since 1963, the
company has put 107 communications satellites into orbit.  With
19 in 1994, this year should be its biggest ever.  In 1993, well
before the Teledesic announcement, Dorfman announced the first
version of Spaceway_a $ 660 million, two-satellite system
offering voice, data and video services_as a contribution to
"information superhighways."

     In the midst of all the terrestrial uproar surrounding
superhighwaymen Al Gore, John Malone of TCI, Raymond Smith of
Bell Atlantic and scores of other telco and cable magnates,
however, no one paid much attention to Hughes.

     Then came Gates and McCaw with Teledesic and claims of 20
million potential subscribers, two million simultaneous
connections, billion-bit-per-second "gigalinks," bandwidth on
demand and an array of other features, all advertised at a cost
for Spaceway-type services nearly three times lower per bit per
second.  Everyone noticed Teledesic.

     At the end of July, though, Hughes raised the stakes.  With
successful launches under way in China, Brazil and French Guiana
to provide exclamation points, Hughes made a new submission to
the FCC, extending Spaceway into a nine-satellite global system
costing $ 3.2 billion.  McGrath plausibly claimed it could be in
place long before Teledesic and offer nearly all its
functionality at a third of the price.

     Already planned to be in place by 1998, however, were
several other LEO projects, led by Motorola's Iridium and
Loral-Qualcomm's Globalstar.  As mobile phone projects, these systems
could not readily offer service at T-1 data rates.  But their
sponsors promised availability for simple E-mail, faxes and
paging.

     By mid-1994, Motorola seemed to command the financial
momentum.  The company succeeded in raising some $ 800 million in
equity investments from companies around the globe, including
Lockheed and Raytheon (which would build the satellites), Great
Wall of China and Khrunichev Enterprises of Russia (which
together would launch a third of them), the Mawarid Group of
Saudi Arabia (which pitched in $ 120 million) and Kyocera, Mitsui
and DDI, which together put up another $ 120 million (Kyocera
will build the dual mode handsets for Japan and DDI will sell and
service them).  On August 10, an Indian consortium purchased a 5%
stake and a seat on the board for $ 38 million.  Motorola claimed
its share of the equity was dropping to 28.5%, well on the way to
the company's final target of 15%.  Motorola estimates that much
of the additional $ 2 billion in the plan could come from  debt
securities and loans.

     Iridium's attractions are impressive.  It provides
ubiquitous global phone service at a premium price with little or
no dependence on local terrestrial facilities.  In times of
disaster or political crisis, or in places with sparse or
unreliable local service, the system can route calls among the 66
satellites in space bypassing all infrastructure on the ground.
For an elite of government officials and corporate figures
operating in remote areas, the availability of Iridium should be
worth the money.  A bold and visionary concept when it emerged in
1987 from a team in the company's satellite systems engineering
group, it endows many regions of the earth with voice and limited
data communications for the first time.  For example, it actually
focuses on polar domains, such as parts of Siberia, poorly served
by other satellite systems.  Kazuo Inamori, the venerable
chairman of Kyocera, also believes that Iridium will be popular
in the 60% of territorial Japan not currently covered by
cellular.

"Give Us Spectrum, Let Others Fight"
     None-the-less, beyond the bold and ingenious concept
(Daggatt calls Iridium "the real pioneer of LEOs"), the system
suffers from technical flaws.  Were it not for Globalstar,
perhaps these flaws would not have become evident until alter the
66 birds were aloft.  A far simpler and cheaper solution,
Globalstar uses 48 satellites with no links between them.  Each
functions as a "bent pipe" transponder, receiving signals from a
phone on the ground and passing them back to any gateway within
the satellite's 1,500-mile-wide footprint, linked to locally
available telephone networks.  Because Globalstar uses local
phone systems rather than bypassing them, the system has been
able to raise a total of some $ 300 million in support from
Alcatel, France Telecom, Vodafone (serving the United Kingdom,
Australia and Hong Kong), Airtouch-U S West, Hyundai and DACOM in
Korea, Deutsche Aerospace and Alenia.

     This amount may seem small beside the billion raised by
Iridium.  But Globalstar has capital costs (at $ 1.8 billion)
one-half Iridium's, circuit costs one-third Iridium's, and terminal
costs (at $ 750 each) one-fourth Iridium's.  With no intelligence
in space, Globalstar relies entirely on the advance of
intelligent phones and portable computer devices on the ground;
it is the Ethernet of satellite architectures.  Costing one-half
as much as Iridium, it will handle nearly 20 times more calls.

     The advantages of Globalstar stem only partly from its
avoidance of complex intersatellite connections and use of
infrastructure already in place on the ground.  More important is
its avoidance of exclusive spectrum assignments.  Originating
several years before spread-spectrum technology was thoroughly
tested for cellular phones, Iridium employs time division
multiple access, an obsolescent system that requires exclusive
command of spectrum but offers far less capacity than code
division multiple access.

     Like conventional cellular or radio transmissions that
differentiate signals by time slot or frequency, TDMA sharply
restricts the reuse of spectrum in nearby cells.  By contrast,
CDMA is a form of spread-spectrum communications that
differentiates signals by a spreading code and allows the use of
the same frequencies all the time, everywhere.  Just as you can
reduplicate wireline spectrum merely by laying another fiber, you
can now manufacture new spectrum in the air merely by breaking
large cells into smaller ones.

     Among some six companies seeking low earth orbit satellite
approval from the FCC in 1993, only Iridium used TDMA, requiring
national and international bodies to pick it as a winner from the
outset and assign it exclusive spectrum.  By contrast, in a
majority report issued to the FCC on April 6, 1993, CDMA
companies in the U.S., including TRW, Loral-Qualcomm, Celsat and
American Mobile Satellite, could all agree to share spectrum and
let the market choose winners.  A Motorola lawyer explained to
Space News, "Give us the spectrum and let the others fight for
whatever's left."  In the face of alternatives with no need for
exclusive spectrum allocations, Iridium could fly only if it
offered radically superior performance or capacity.  But TDMA
dooms it to generally inferior performance and capacity.

     Unlike TDMA systems, which can "see" only one satellite
signal at a time, CDMA handsets have "path" diversity, using
"rake receivers" that can combine a number of weak signals into
an intelligible stream.  Iridium and other TDMA systems
compensate by using more power.  But no practical amount of power
can propel a satellite signal through a tin roof.  And excess
power means larger handsets or heavier satellites.  Iridium
satellites together use 80% more power than Globalstar's, yet
employ antennas nearly twice as large and offer 18.2 times less
capacity per unit area.

     Teledesic also suffers from the use of TDMA.  But
Teledesic's T-1 capabilities would compensate with 100,000 times
more bandwidth and with a bit error rate that can accommodate the
new fiber standards such as SONET-ATM (synchronous optical
network/asynchronous transfer mode), which send packets without
retransmission.  The issue is whether these features can justify
the political, financial, and performance costs of using a
modulation scheme_TDMA_that severely limits spectrum sharing and
path diversity.

     So what is this, another saga of hubris on the information
super-highway_to go with the Raymond Smith-John Malone follies?
Perhaps good new ideas are harder to come by as company revenues
grow into the billions, and Gates and McCaw disinvest and
diversify as fast as they can from their increasingly cumbrous
vessels of wealth.  Having recently passed the billion-dollar
mark in his systematic process of disinvestment from Microsoft_he
retains $ 8 billion or so_Gates at times seemed embarrassed by
his link to this gigantic project.  He told us it was too early
to write about Teledesic.

     No, the story is in fact more interesting.  Impelled by the
onrushing rise in the cost-effectiveness of individual chips
compared to multichip systems, the Law of the Microcosm dictates
decentralization of all information architectures.  During the
1980s, this centrifuge struck the mainframe computer
establishment of IBM.  During the 1990s, the personal teleputer,
summoning and shaping films and files of images from around the
world, will collide with the centralized establishments of TV
broadcasting.  At the end of the century, Teledesic and the other
LEOs will usher in the age of decentralization in space.

     From this point of view, Gates' participation becomes more
readily intelligible.  Gates seems always to follow the microcosm
wherever it leads.  A vision of software for decentralized
systems of personal computers informs everything Microsoft
does.

     In 1994, for example, Microsoft made an investment in
Metricom, a wireless terrestrial system that supplies links of up
to 56 kilobits per second to portable computers or personal
digital assistants.  Within cells, the devices can communicate
directly with one another; outside the cell, Metricom routes its
calls through an expandable mesh of nodes each the size of a
shoebox and costing less than $ 1,000.  Based on spread-spectrum
technology, the system operates at power levels low enough to
avoid the need for FCC licenses.  Yet it can be expanded to
metropolitan-area dimensions.

     In many respects, Teledesic is Metricom in the sky.  It is
focused on computer communications.  It routes packets by the
most convenient path through a mesh of nodes.  It is based on
microprocessor technology.  (Both Teledesic and Metricom plan to
employ devices from Motorola's 68000 family).  As Gates explains
the system: "Some functions are most efficiently performed by
large numbers of small processors working together, rather than a
few large ones."  The entire new generation of low earth orbit
satellite systems relies on this centrifugal force of the
microcosm.

     It was not supposed to happen this way.  Just as Grosch's
Law of the computer industry implied that computer power rose by
the square of the cost, there was a similar law of the satellite
industry that held satellite efficiency to be proportional to
see.  In a popular text, "Communications Satellite Systems,"
published in 1978, James Martin cited an AT&T study showing that
just six satellites could carry all the long-distance traffic
from the American continent; no fiber optics would be necessary.
"The next major thrust in the space segment should capitalize on
the economies of scale which today's technology offers," wrote
Martin, urging creation of "massive hardware" as heavy as several
tons and "immensely powerful satellites with large antennas
beaming as much information as we are capable of using to our
rooftops."  Many satellite advocates, led by Arthur C. Clarke,
viewed with impatient scorn the expensive terrestrial systems
that somehow forestalled the manifest destiny of big birds to
rule the world of communications.

Bringing The Microcosm To Space
     In 1994, the big bird dream still flourishes in Spaceway,
the international consortium Inmarsat, and the new launch this
summer of direct broadcast satellite technology by Hughes's
DirecTV, Hubbard's USSB, TCI's Primestar, and Rupert Murdoch's
imperial systems in Europe and Asia.  Using centralized
satellites in geosynchronous orbits, DBS is the ultimate
broadcast medium, reaching billions of potential customers at the
cost of reaching hundreds of thousands through cable-TV systems.
But these geostationary satellite systems suffer from the same
flaws as mainframes: sclerosis by centralization.  At a time when
customers want the choice, control, convenience and interactivity
of computers, the big birds offer one-size-fits-all programming
at specified times, with little ability to control the flow or
interact with it.

     The real showstopper in the long run, though, is a nagging
half-second time delay for Clarke orbit signals.  Bad enough for
voice, a half-second is near eternity for computer communications;
for the living-room and desktop supercomputers of 2001, a
half-second delay would mean gigabytes of information to be stored
in buffers.  While companies across the country, from Intel to
Digital Equipment, are rushing to market with cable modems to
allow computer connections to CATV coax, geosatellites remain
mostly computer-hostile.  Even with the new digital cosmetics
of DBS, geosynchronous satellites are a last vestige of
centralization in a centrifugal world.

     By contrast, Teledesic brings the microcosm to space.
Rather than gaming economies of scale from using a few huge
satellites, Teledesic gains economies of scale by launching as
many small birds as possible.  Based on Peter Huber's concept of
a geodesic network_a mesh of peers equally spaced apart like the
nodes in a geodesic dome_Teledesic is not a hierarchy but a
heterarchy.  Distributing the system responsibilities among 840
autonomous satellites diminishes the requirements, such as
message throughput and power usage, for each one.  Building
redundancy into the entire constellation, rather than within each
satellite, yields higher overall reliability, while reducing the
complexity and price of each unit.

     As Craig McCaw explains, "At a certain point, redundant
systems create more complexity and weight than they are worth.
Rather than having each satellite a 747 in the sky with triply
redundant systems, we have hundreds of satellites that offer
self-redundancy."  Eschewing the Hughes philosophy of "every
component proprietary to Hughes,"  Teledesic will manufacture and
launch a large number of satellite peers, using off-the-shelf parts
whenever possible.  This approach also provides economies of scale
that, according to a study by brilliant pebbles contractor
Martin Marietta, could lower unit costs by a factor of one
hundred or more.

     Just as microcosmic technology uses infinitesimal low-powered
transistors and puts them so close together that they work faster
than large high-powered transistors, Teledesic satellites follow
the rules of low and slow.  Rather than one big powerful bird
spraying signals across continents, Teledesic offers 840,
programmably targetable at small localities.  Just 435 miles out,
the delay is measured in milliseconds rather than half-seconds.

     The total computing power and wattage of the constellation
seems large, as is needed to sustain a volume of some two million
connections at a time, four times Spaceway's capacity.  But with
other link features equal, between 1,226 and 3,545 times more
power is needed to communicate with a geostationary satellite
than with a LEO.

     Perhaps most important, unlike Iridium, TRW's Odyssey, and
Globalstar, Teledesic from the outset has targeted the fastest-
growing market of the future: communications for the world's 125
million PCs, now growing some 20% a year.  And Teledesic has
correctly chosen the technology needed to extend computer
networks globally_broadband low earth orbit satellites.  The real
issue is not the future of Teledesic but the future of Iridium.

     In the short run Iridium's voice services cannot compete
with Globalstar's cheaper and more robust CDMA system.  But in
the long run Iridium could be trumped by Teledesic.  Although
Teledesic has no such plans, the incremental cost of
incorporating an "L" band transceiver in Teledesic, to perform
the Iridium functions for voice, would be just 10% of Teledesic's
total outlays, or less than $ 1 billion (compared with the $3.4
billion initial capital costs of Iridium).  But 840 linked
satellites could offer far more cost-effective service than
Iridium's 66.

     Iridium's dilemma is that the complexities and costs of its
ingenious mesh of intersatellite links and switches can be
justified only by offering broadband computer services.  Yet
Iridium is a doggedly narrowband system focused on voice.

     Iridium eventually will have to adopt Teledesic's broadband
logic and architecture.  To protect its global lead in wireless
communications and equipment, Motorola should join with Teledesic
now, rather than later.  Working with Lockheed, Motorola is
making impressive gains in satellite-manufacturing technology.
Supplying both handsets and space gear for computer networks,
Motorola could turn its huge investment of time, money and
prestige in Iridium into a dramatic global coup in wireless
computer services.  As part of a broadband system, Iridium could
still become a superb brand name for Motorola.  But persisting in
a narrowband strategy in the name of avoiding Teledesic's larger
initial costs, Motorola's executives will end up inflicting
serious strategic costs on the company.

     Most of the famous objections to Teledesic are based on
ignorance or misinformation.  Launch anxieties spring chiefly
from the GEO experience.  LEOs are 60 times nearer and between a
tenth and a third the weight.  Teledesic satellites are designed
to be hoisted in groups of eight or more.  From Great Wall in
China to Khrunichev in Russia, companies around the world will
soon be competing to supply low-cost launching facilities for the
system.  Orbital Sciences, an entrepreneurial dervish near
Washington's Dulles Airport with some $ 190 million in revenues,
has developed a low-cost method for lofting groups of LEOs from
an adapted Lockheed 1011 Tristar.

     Other fears are similarly fallacious.  Teledesic will work
fine in the rain because the high minimum vertical angle (40
degrees) of its satellite links from the ground reduces the
portion of the path exposed to water to a manageable level.  By
contrast, geostationary satellites must operate at eight degrees,
passing the signal through a long span of atmosphere.  Made of
tough new composite materials, Teledesic satellites will endure
the kind of debris found in space mostly unscathed.  The solar
arrays can accept holes without significantly damaging overall
performance.  All in all, Teledesic's designers expect the birds
to remain in orbit for an average of ten years.  With most of its
key technologies plummeting in price along with the rest of
electronic components, the system may well cost even less and
perform better than its business plan promises or George Fisher
speculates.

     Indeed, widely charged with reckless technological
presumption, the designers of Teledesic in fact seem recklessly
cautious in their assumptions about the rate of microchip
progress.  For example, their dismissal of CDMA assumes that the
high speed of the spreading code functions_requiring digital
signal processors that race at least 100 times the data
rate_pushes cheap T-1 performance far into the future.  Yet in
early 1995, Texas Instruments will ship its multimedia video
processor, a marvel that combines four 64-bit DSPs, a 32-bit RISC
CPU, 50 kilobytes of on-chip memory, a floating-point unit and a
64bit direct memory access controller all on one chip.  This
device now performs two billion operations per second and, with
an upgrade from 35 megahertz to 50 megahertz clock rate, soon
will perform three billion.  The estimated cost in 1995 is around
$ 400, or a stunning $ 133 per bop (current Pentiums charge three
times as much for 100 mips).  Five years from now, when Teledesic
gets serious, that kind of one-chip computing power can implement
CDMA for broadband data without any cost penalty.  Future
generations of CDMA systems may be able to offer, at a dramatically
lower price, the same broadband services in mobile applications
that Teledesic now promises for fixed services only.

     Assuming that Teledesic meets the CDMA challenge, the other
fear is that terrestrial systems will capture enough of the
market to render Teledesic unprofitable.  This fear, however, can
come true only if governments delay this supremely beneficial
system well into the next century.

     Unlike the competition, satellite systems can provide global
coverage at once.  Whether for $ 9 billion or $ 90 billion, no
terrestrial system will cover the entire world, or even the
entire U.S., within decades of Teledesic.  As soon as it is
deployed, it will profoundly change the geography and topography
of the globe.  Suddenly the most remote rural redoubt, beach, or
mountain will command computer communications comparable to urban
corporations today.  The system can make teleconferencing,
telecommuting, telemedicine, and teleschooling possible anywhere.
Gone will be the differences among regions in access to cultural
and information resources.  People will be able to live and work
where they want rather than where corporations locate them.

     This change transforms the dimensions of the world as
decisively as trains, planes, automobiles, phones and TVs changed
them in previous eras.  It will extend "universal service" more
dramatically than any new law can.

     Moreover, Teledesic can eliminate the need to cross-subsidize
rural customers.  Determining the cost of wire-line services are
the parameters of population density and distance from the central
office.  Rural customers now cost between 10 and 30 times as much
to serve with wires as urban customers do.  Teledesic will bring
near-broadband capabilities to everyone in the world at the same
price.

     Most important, this expansion of the communications
frontier will foster the very economic development that will fuel
the demand for the service.  Today, it does not pay to bring
telecommunications to poor countries that might benefit most.
Teledesic and other satellite services break the bottleneck of
development.  Simultaneously opening the entire world, it
enriches every nation with new capital exceeding the fruits of
all the foreign aid programs of the era.

     Teledesic is a venture worthy of McCaw and Gates.  In its
impact on the world, it may even rival the Herculean
contributions of its sponsors in cellular and software.  The
issue is not the technology or the commitment of the principals.
The issue is the readiness of the U.S. government to accommodate
this venture.  Before Teledesic can be approved internationally,
it will have to attain a license from the FCC in the U.S.  It has
taken four years to approve Iridium.  It took 30 years to approve
cellular.  How long will it take to approve Teledesic?

     Currently Teledesic, Iridium and Globalstar face several
political obstacles.  The International Telecommunications
Union's Radio Regulation 2613 gives GEOs absolute priority over
LEOs.  For Spaceway, Hughes is now demanding an exclusive license
for the full five gigahertz available in the Ka-band worldwide,
leaving no room for Teledesic or any other Ka-band LEO.  Under
current law, Hughes or other GEO systems could usurp any LEO that
was launched.

     LEOs are a major American innovation.  The U.S. government
should take the lead now in spearheading a change in the
regulations to accommodate LEOs.  This is no minor matter.  As
the dimensions and promise of Teledesic loom more starkly, the
Japanese or Europeans are certain to make similar proposals.
"When they do," Craig McCaw predicts, "they will immediately have
their government on board.  They will be able to go to the ITU
right away.  My greatest fear is that we will have the technology
all ready, and foreign companies will beat us out because they
can get their governments in line."

     The U.S. government was on board for Apollo 25 years ago and
the U.S. won the first space race.  This space race is just as
important, but the government is treating it as some sleepy-time
infrastructure project.  In fact, it is the information
superhighway going global and ubiquitous.  It is the ultimate
promise of the information age, says McCaw.

Sustaining The U.S. Lead In Technology
     McCaw explains: "It'll mean ecological disaster if China
mimics what we did_building more and more urban towers and
filling them up with people who queue up every day on turnpikes
into the city, emitting fumes into the air, and then building new
towers and new highways when you want to move the company, and
then digging up the highways to install new wires."

     McCaw waves toward the window, out at Lake Washington.
"Look at that floating bridge.  It took $ 1.5 billion to cross
Lake Washington, then it got busted in a storm.  Cross this lake,
any lake, any ocean in the world with broadband wireless.  That's
the promise of Teledesic.  All you do is to reconfigure the
communications in software at zero incremental cost.  No wires
for the final connections.  It's what we do in Hong Kong and
Shanghai, where everyone uses a cellular phone."

     President Clinton, Vice President Gore and other members of
the administration continually ask what they can do for
technology.  One thing they can do is vastly streamline the
process for approval of communications projects.  At the moment,
Congress is determined to retain bureaucratic dominance over the
most dynamic enterprise and technology in the world economy_what
they like to term the information superhighway.  They see it as a
possible source of congressional power, campaign finance,
employment and pelf, like the Baby Bells today or like existing
construction projects.  Rather than turn telecom into a vast
porkbellied poverty program, however, the administration should
deregulate the field.  Communications companies must be permitted
to compete and collaborate wherever the technology leads.

     Whether the administration knows it or not, these
technologies are its greatest political asset.  The high-tech
industries unleashed in the 1980s by venture capital and junk
bonds are now the prime fuel of the economy of the 1990s.
Comprising perhaps 60% of incremental GDP and 48% of exports, the
momentous upsurge of computers and communications is even
compensating for the mistakes of the Bush and Clinton regimes and
making plausible Clinton's continuing claims of economic success.
But now Clinton, Gore and FCC Chairman Reed Hundt must make a
choice.  If they want to maintain this redemptive U.S. lead in
technology, they must be willing to forge new alliances in
Congress to get the politicians and bureaucrats out of the way of
the future.  A good start would be to open the floodgates for the
global onrush of low earth orbit satellites dedicated to computer
communications.  If they do, they can help make the world, as
McCaw's Alberg puts it, "a truly global Internet in an ever-expanding
ethersphere."

And The Winner Is...
     Globalstar is the easy winner for current offering of mobile
phone services under a CDMA regime of spectrum sharing.  But
Teledesic can add phone services to its broadband computer
system.  Over time, Teledesic's 840 satellites will outperform
Globalstar's 48.  Big question: When will microchip technology
advance enough to allow broadband applications over CDMA?  When
that happens, Globalstar has a shot at the grand prize.

     Iridium is both too expensive to compete in mobile phones
and too narrowband for data.  Today's champ Spaceway is maturing.
Big winner for the next decade is... Teledesic.

#####

Wireless Retina Implant

Retina Implant

AG Announces the Publication of Study Results on its Alpha IMS Implant in Proceedings of the Royal Society B



Ba

REUTLINGEN, Germany (February 20, 2013) —Retina Implant AG, the leading developer of subretinal implants for patients blinded by retinitis pigmentosa (RP), today announced results from part of its multicentre study were published today in the peer-reviewed journal Proceedings of the Royal Society B. The research found that, during the course of a three to nine month observation period, functional vision was restored in the majority of nine German patients implanted with a subretinal microchip as part of the first module of the Company’s second human clinical trial. In addition, visual acuity for two of the nine patients surpassed the visual resolution of patients from the Company’s first human clinical trial.
The study titled “Artificial Vision with Wirelessly Powered Subretinal Electronic Implant Alpha IMS” was led by researchers at the University Eye Hospital in Tuebingen, Germany including Professor Eberhart Zrenner and Katarina Stingl, M.D. Patients were implanted with Retina Implant AG’s subretinal wireless 3x3 mm2, 1500 pixel Alpha IMS microchip and are able to adjust the level of stimulation received to view objects at varied distances. Of the nine patients observed in the study, three patients were able to read letters spontaneously. During observation in and outside the laboratory patients also reported the ability to recognize faces, distinguish objects such as telephones and read signs on doors.
“The results of our first human clinical trial exceeded our expectations, and we are further encouraged by the results from the second human trial,” said Professor Eberhart Zrenner, M.D., lead clinical trial investigator, Institute for Ophthalmologic Research at University Eye Hospital Tuebingen, Germany. “As physicians, we are constantly seeking out the best treatment options for our most in-need patients, which most definitely includes those suffering from advanced-stage retinitis pigmentosa. This research provides additional evidence that our subretinal implant technology can help some patients with retinal degeneration regain functional vision and does so in a way that does not require externally visible equipment.”
“The continuation of our trial and publication of this module is the next milestone in our quest to secure CE mark approval and provide RP patients living in darkness with a treatment option,” said Walter-G Wrobel, president and CEO, Retina Implant AG. “We are continually humbled by the 36 patients we’ve implanted thus far and their willingness to participate in this ground-breaking research.”
The Company’s first clinical trial began in Germany in 2005, where 11 patients suffering from retinitis pigmentosa were implanted with a subretinal microchip below the retina in the macular region. Results from the first trial were published in November 2010 in Proceedings of the Royal Society B, concluding that the implantation of Retina Implant’s microchip was successful in restoring useful vision in patients previously blind due to retinitis pigmentosa. The second clinical trial with a wireless device that allows patients to use the implant outdoors and at home began in May 2010 in Tuebingen, Germany, and has since expanded into the multicentre phase of the trial with implants taking place in Hong Kong and the UK.
“As a leading relevant patient organisation in the UK we have been watching Retina Implant AG’s research with great interest,” said David Head, CEO of RP Fighting Blindness. “The results published today show definite promise to one day restore functional vision to patients with advanced-stage retinitis pigmentosa.”
About Royal Society Publishing
The Royal Society is a self-governing Fellowship of many of the world’s most distinguished scientists drawn from all areas of science, engineering, and medicine. The Society’s fundamental purpose, as it has been since its foundation in 1660, is to recognise, promote, and support excellence in science and to encourage the development and use of science for the benefit of humanity.
The Society’s strategic priorities emphasise its commitment to the highest quality science, to curiosity-driven research, and to the development and use of science for the benefit of society. These priorities are:
1.       Promoting science and its benefits
2.       Recognising excellence in science
3.       Supporting outstanding science
4.       Providing scientific advice for policy
5.       Fostering international and global cooperation
6.       Education and public engagement

Retina Implant

http://retina-implant.de/en/doctors/technology/default.aspx


What are visual implants?

"...Generally speaking, an implant or prosthesis in the field of medicine designates a device which takes over the functions of organs or their parts. In this sense, many types of implants and prostheses have already been introduced in the field of ophthalmology - artificial lenses, corneal implants, iris implants, filtration implants in glaucoma surgery and - in the narrower sense of the word - silicone oil. To be understood under "visual implants", however, are technical devices which seek to take over the neuronal functions of vision. We speak here of "artificial sight".
Various approaches exist for the use of visual implants. Corresponding to the visual pathway itself, there are subretinal, epiretinal, optic nerve and cortical visual implants.
In principle, the subretinal implant [1 - 3] replaces the photoreceptors in retinitis pigmentosa or other forms of retinal degeneration in which the inner retina and the rest of the visual pathway remain intact. Such a neurological implant converts incident light into an electrical signal which is then transmitted on to the bipolar cells.
 An epiretinal prosthesis [4 - 7] directly stimulates ganglion cells and is positioned on the nerve fibre layer. Epiretinal implants work with an external camera mounted on a spectacles frame and require an "encoder" whose function is to take over the role of the neurons of the inner retina, which carry out preliminary processing of visual information. A problem encountered in stimulation of the ganglion cells with this method is that there is usually no stimulation of fibres in the vicinity of the original cell when the stimulus is transmitted from the original retinal cell to the papilla of the eye. For its part, the brain invariably interprets excitement of such a fibre as a specific point of light within the visual field.
This point of light corresponds to the location of the original cell in the retina, but not to the location of the electrode. For that reason, an image generated with this method must first be assembled with "spatial accuracy" before it is transmitted to the fibre side of the retina. This task can, for example, be taken over by a 'learning' software, that is, by an "encoder" which shifts the stimulus location in each case within the image field to match the actual visual sensation within the visual field - a complex assignment for which the required hardware cannot presently be located within the eye.
The subretinal implant, on the other hand, is positioned at the level of the photoreceptor layer and can thus make full, correct use of the retinotopy of bipolar cells linked to it. This is a major difference from the epiretinal approach, in which a camera is mounted on a spectacles frame and the patient must regularly move his head – that is, the camera - back and forth; to prevent the image from disappearing, as in the case of stabilized retinal images. With the subretinal approach, in which light receivers are located beneath the retina, assistance is provided by natural microsaccades which constantly refresh the image. In addition, the eye's direction of gaze can be used to find the object viewed without need of resorting to movement of the head. On the other hand, no overall change in image processing can take place after implantation of the active subretinal implant, since its image-processing electronics are completely within the body. It has been found, however, that due to the very good retinotopy the adjustment of sensitivity and maximum brightness provide adequate possibilities for varying adjustment.
Like epiretinal prostheses, optic nerve implants [8] stimulate the axons of the optic nerve and likewise function with an external camera. Even though retinotopy within the optic nerve is demonstrably preserved, the high density of the axons makes it impossible to achieve a high level of resolution. Cortical implants [9] directly stimulate the neurons of the primary visual cortex and require a very elaborate surgical procedure.
Currently, the visual implants developed farthest are the epiretinal and subretinal implants. Although both have advantages and disadvantages the best three-dimensional resolution, visual acuity, and stability of visual perception to date have been attained with the subretinal approach[10, 17].
In a collaborative effort with the University of Tübingen's Ophthalmological Clinic, a subretinal chip has been undergoing development since 1995 [18]; following successful animal trials [1, 11 - 15], implantation in blind patients began in 2005. A pilot study from 2005 to 2009 showed that such implants represent no major risk for the human retina and that it is possible to mediate meaningful visual perceptions by means of this subretinal chip. Currently, we have been using a technologically improved implant, the Alpha IMS, since May 2010 in a multicentre study with blind retinitis pigmentosa patients.
Picture of the subretinal implant in detail
Figure 1) Detailed view of the subretinal implant on the microchip, which for its part has 1,500 pixels on a surface area of 3×3 mm. The chip consists of 1,500 microphotodiodes, each of which is connected to an amplifier and an electrode. Each microphotodiode collects the incident light signal, and an amplified electrical signal is sent by the electrode to the bipolar cells. The entire implant consists of the subretinal chip, a power supply cable (polyimide film and a thin silicone cable with gold wires), and the secondary coil, which is affixed to bone in the retroauricular region.

How does the subretinal chip function?

In a healthy retina, light is converted by the photoreceptors into nerve signals through a change in cell membrane polarization. The subretinal implant takes over this function. For its part, the 70 µm-thick microchip consists of 1,500 elements ("pixels") on a surface area of 3 × 3 mm (● see Figure 1). Each of these elements contains a silicon photodiode, a differential amplifier, and an electrode. Incident light is collected point for point by the photodiodes and converted into electrical signals. An amplifier downline from each photodiode passes on an adequately strong electrical charge to the bipolar cells of the retina via electrodes. Since this process takes place in each pixel independently, the natural retinotopy of the visual signal is preserved with geometrical correctness.

In contrast to the natural photoreceptors, however, the energy of incident light does not suffice to directly stimulate the cells of the inner retina. For that reason, subretinal visual implants require an external power supply. The entire implant therefore consists not only of the microchip but also of a subdermal power supply behind the ear with a connecting cable (● see Figures 1, 2, 4).
The chip is connected to its power supply unit via a 20 µm-thick sheet of polyimide film and a thin silicone cable with gold wire (● see Figure 1). The energy transfer to this power supply takes place via electromagnetic induction through a subdermal secondary coil and an epidermal primary coil which is held magnetically in place (● see Figure 2).
Picture of the external power supply

 

Figure 2a) The external power supply with the external primary coil.




This picture shows the position of the primary coil on the patient's head
 

Figure 2b) The primary coil is magnetically held in position in the retroauricular region at the position of the secondary coil and is always positioned there for the purpose of activation of the implants. Energy transfer between the two coils takes place via electromagnetic induction.



Picture of the control device which is used by the patient



Figure 2c) Adjustment of the perceptual parameters (depending on the brightness and contrast of the objects to be viewed) is carried out manually by the patient himself by means of the external power supply.
 
  
An external power supply unit delivers pulsed energy to the primary coil. The chip as a whole uses its 1,500 microphotodiodes to record an electrical image several times a second for 1 ms and send it on to the bipolar cells.
The chip is surgically implanted [16] and positioned subretinally - if possible directly beneath the macula (● see Figure 3). 
The picture shows the retina implant as it gets implanted



Abbildung 3) The subretinal microchip is implanted at the posterior pole of the eye, if possible beneath the macular area. The surface area of the active implant is 3×3 mm. The strip with the cable connections leads to the retinal periphery.


The polyimide film is also positioned subretinally and exits from the eye at the equator through the choroid and the sclera. This part of the implant is held in place through intraocular pressure alone. The transition to the silicone cable is mounted episclerally. The cable then runs intraorbitally to the  bony edge of the orbit of the eye, to which it is likewise affixed. From there, the cable runs below the temporal muscle to the secondary coil, which is mounted on bone in the retroauricular region (● see Figure 4). The cable is adequately secured by being laid under the periosteum. The power supply too is below the periosteum, if necessary in a precisely shaped hollow which is milled out of the bone. .
Scheme of the subretinal implant's position in the eye

 

Figure 4a) Intraocular position of the subretinal implant. The microchip itself is positioned subretinally below the macula. The tiny band which connects the microchip with the power supply cable runs subretinally into the retinal periphery and exits transchodioidally and transsclerally out of the globe.



This computer generated image shows the positioning of the coils



Figure 4b) The power supply cable exits from the orbit at the lateral bony edge of the orbit of the eye and passes under the masseter muscle into the retroauricular region, where it is attached to the secondary coil. Taking a leaf from cochlear implants, the latter is surgically attached to the bone and is supplied with power for activation of the implant via electromagnetic induction by the externally positioned primary coil...."

 

(From: Stingl K et al., Klin Monatsbl Augenheilkd, 2010; 227: 940-945)

Literature

[1] Zrenner E. Will retinal implants restore vision? Science 2002; 295:1022–1025
[2] Zrenner E, Gekeler F, Gabel PV et al. Subretinal microphotodiode array as replacement for degenerated photoreceptors? Ophthalmologe 2001; 98: 357–363

[3] Gekeler F, Zrenner E. Status of the subretinal implant project. An overview. Ophthalmologe 2005; 102: 941–949

[4] Yanai D et al. Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Am J Ophthalmol 2001; 143: 820–827

[5] Horsager A, Greenberg RJ, Fine I. Spatiotemporal interactions in retinal prosthesis subjects. Invest Ophthalmol Vis Sci 2010; 51: 1223–1233

[6] Chader GJ, Weiland J, Humayun MS. Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res 2009; 175: 317–332

[7] Hornig R, Laube T,Walter P et al. Amethod and technical equipment for an acute human trial to evaluate retinal implant technology. J Neural Eng 2005; 2: S129–S134

[8] Brelen ME, Vince V, Gérard B et al. Measurement of evoked potentials following electrical stimulation of the human optic nerve. Invest Ophthalmol Vis Sci 2010 10.1167/iovs.09-4346

[9] Normann RA, Greger B, Greger BA et al. Toward the development of a cortically based visual neuroprosthesis. J Neural Eng 2009; 6: 035001

[10] Humayun MS, Dorn JD, Ahuja AK et al. Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility study. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 4566–4568

[11] Zrenner E, Stett A, Weiss S et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 1999; 39:2555–2567

[12] Schwahn H, Gekeler F, Kohler K et al. Studies on the feasibility of a subretinal visual prosthesis: data from Yucatan micropig and rabbit. Graefe’s Archive for Clinical and Experimental Ophthalmology 2001; 239:961–967

[13] Kohler K, Hartmann JA, Werts D et al. Histological studies of retinal degeneration and biocompatibility of subretinal implants. Ophthalmologe 2001; 98: 364–368

[14] Guenther E, Tröger B, Schlosshauer B et al. Long-term survival of retinal cell cultures on retinal implant materials. Vision Res 1999; 39: 3988–3994

[15] Zrenner E, Miliczek KD, Gabel VP et al. The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. Ophthalmic Res 1997; 29: 269–280

[16] Besch D et al. Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: feasibility and outcome in seven patients. British Journal of Ophthalmology 2008; 92:1361–1368

[17] Zrenner E, Wilke R, Bartz-Schmidt KU. et al. Subretinal Microelectrode Arrays Allow Blind Retinitis Pigmentosa Patients to Recognize Letters and Combine them toWords. Biomedical Engineering and Informatics 2009. BMEI ’09. 2nd International Conference, Tianjin, 17 – 19 Oct 2009: 1–4 10.1109/BMEI.2009.5305315

[18] Zrenner E. Restoring neuroretinal function: new potentials. Doc Ophthalmol 2007; 115: 56–59

Microchips in the Eye

http://www.mddionline.com/article/microchips-eye


Published: February 3, 2011
Find more content on: 


Microchips in the Eye


Electronic retinal implants are gaining popularity as research into the technology continues to show improvements for patients.

About 30 research groups worldwide are currently working on an electronic retinal implant. Retina Implant AG, a company in Reutlingen, Germany, has conducted a successful clinical pilot study demonstrating that the technique of subretinal stimulation permits visual recognition of patterns and letters of the alphabet. This study confirms electronic retinal implants can give very useful visual perceptions to the blind (See three videos regarding Retina AG study results and demonstrations).
Subretinal Implant photo courtesy of Retina Implant AGHereditary retinal degeneration (retinitis pigmentosa) results in a progressive loss of photoreceptors and in most cases leads gradually to a complete loss of vision. More than 100,000 people in the United States and an estimated three million people worldwide suffer from various forms of this disease. Although drugs are currently under development, there is as yet no therapy for this ailment. However, many of those affected may soon be able to recover a certain degree of vision by means of an implanted camera chip.
In the normal eye, incident light passes through the transparent tissue of the retina and falls on some 120 million rods and six million cones at the fundus of the eye. The light is converted in a multiple-stage process into electrical signals. These signals undergo preliminary processing in the underlying layers of bipolar, horizontal, and amacrine cells and are then passed on to the ganglion cells. For their part, the axons of the ganglion cells communicate with the optic nerve, which forwards the information gained thus far to the visual cortex (i.e., visual center) of the brain.

Subretinal Implants

Diseases like retinitis pigmentosa (RP) are distinguished by the fact that a large part of the retina remains functional even after loss of sight. Although the rods and cones that normally convert light into nerve signals are destroyed by this disease, most of the retinal nerve tissue, which has the task of pre-processing information on its way to the brain, remains intact. In other words, the visual apparatus is functional; it just lacks input. Based on this concept, Eberhart Zrenner at the University Eye Clinic of Tübingen has developed a subretinal implant in cooperation with that university’s Institute of Natural Science and Medicine (NMI).
For the university’s implant, natural optical stimulus is simply replaced by pulsed, light-dependent electrical stimuli, resulting in the perception of phosphenes (artificially triggered light phenomena). Because the electrical excitation invariably involves a number of cells, the patients cannot visualize objects sharply, but are nevertheless able to locate light sources and localize physical objects.
diagram of eye showing subretinal chip
The subretinal chip replaces the degenerated photoreceptors. 
The implant is located subretinally, i.e. behind the retina. From an anatomical point of view, it exactly replaces the photoreceptors that have been lost (see Figure 1). From the viewpoint of signal processing, this is an all-important advantage; the implant’s subretinal excitation exploits the full range of neuronal circuitry in the retina along the way to the optic nerve. The electrical signal is triggered at the point of brightness, and the stimulation strength corresponds to the intensity of the incident light. The optical image is thus exactly replaced by an electrical pattern of excitation.
The retinal implant consists of a silicon chip about 3 × 3 mm in size and 70-µm thick, with 1500 individual pixels. Each of these pixel cells contains a light-sensitive photodiode, a logarithmic differential amplifier, and a 50 × 50-µm iridium electrode into which the electrical stimuli at the retina are guided. The circuitry was developed in collaboration with the IMS in Stuttgart and is made by applying 0.8-µm CMOS technology.2 The result is a pure analog chip, with the advantage that its power consumption is very low (maximum 10 mW), and the heat passed on to the retina by electrical power from the chip remains below 0.5 K. The microchip is positioned on a thin, highly flexible circuit board of polyimide with gold circuits that transmit power and control signals (See Figure 2). The very fine polyimide strip is connected in turn to a thin, coiled cable through which the electricity of the chip is supplied. This elastic cable passes through the orbital cavity to the bone of the temple and from there to a point behind the ear, where it is connected to an inductive power supply unit in a ceramic housing. The electrical energy is received inductively from the outside through a second coil that is located on the skin. Permanent magnets in the two coils ensure close contact.
camera chip with silicone cable connects wirelessly to power reciever
The CMOS camera chip on polyimide carrier is connected via a silicone cable to the wireless power receiver.5
All of the components must of course be biocompatible—that is, well tolerated by the body—and must possess long-term stability. This is an enormous technological challenge that requires, among other things, the use and combination of new materials. The components must be provided with a hermetically sealed protective layer at the point of contact with the surrounding tissue. They must undergo numerous tests to demonstrate the device’s ability to withstand the corrosive environment within the body. An especially critical point is that the presence of electrical voltage can greatly accelerate the corrosion process. The selection of materials and the manner in which they are processed is critical.
Above all, the electrodes and their contact points on the chip are of decisive importance. The useable electrode surface must be as small as possible but also offer as large a surface as possible to ensure good contact with the retina. For this reason, the electrodes are manufactured of fractal iridium, whereby the materials permit a higher transmission of charges.
Optimal visual perception is present when pulse durations are around 1 microsecond and the charge amounts to 2–5 nC per pixel. This corresponds to a voltage of up to 2 V. The repetition rate of excitation is normally 5–7 Hz, because higher rates would result in overstimulation of the retina. The patient’s visual perception therefore flickers somewhat.

Clinical Studies and Results

During a clinical pilot study at the University Eye Clinic in Tübingen, the retinal implant was first tested over a period of up to four months in 11 patients. The development of a new type of surgical procedure was given high priority in collaboration with the University Eye Clinic in Regensburg, Germany. It involves creating a small access opening through the external sclera of the eye. After removal of the vitreous, the retina is lifted up from its underlying support layer so that the flexible film with the chip can be advanced under the retina to the vicinity of the macula. This is the point at which density of the nerve cells is greatest and can be expected to result in the most effective stimulation. Following exact positioning, the small window through the sclera is again closed, thus attaching the film securely in the globe of the eye so that the chip can assume a stable position and is not subjected to tension due to movements of the eye.
subdermal power supply cabling implant
Subdermal positioning of power supply and cabling for the subretinal implant.
It was already possible to conduct initial tests with the patients only one week after implantation. The majority of patients recognized not only horizontal and vertical lines but also the direction in which electrodes were activated one after another and simple geometric patterns. However, the threshold value for triggering a stimulus varied widely in the different patients. In some cases, it was possible to trigger a phosphene with individual electrodes and a charge transfer of only a few nanocoulombs. However, many of the patients experienced visual perception only when several adjacent electrodes were stimulated simultaneously.3 The causes of these patient-specific threshold values may be both the position of the electrodes relative to the macula and the distance between the electrodes and the bipolar cells in the retina.
Most of the patients reported blurred visual perception. Many were able to distinguish light sources or bright objects against a dark background. As the ability to recognize objects grew in each patient, it became possible to continuously optimize the stimulation parameters and the position of the chip in the eye so that three of the 11 patients were reliably able to recognize simple patterns when the chip was turned on and even bright objects against a dark background. In fact, the last test subject correctly recognized letters of the alphabet that measured ca. 8 cm high, was able to localize people in a room, and identified their size. A standard visual examination of this patient with Landolt C Rings resulted in a visual acuity of 1/50, which is slightly above the threshold of legally defined blindness (according to WHO). This was conclusive proof that the basic concept of the subretinal implants functions successfully and can lead to usable visual perception.4
The learning effects that the authors observed were noteworthy: the patients needed only a few hours to learn how to process visual perceptions that were new to them. One patient who had been completely blind for the last 15 years was able to see the letters of the alphabet, and told the investigator that the letters looked “exactly as I learned them at school.” When his name was presented to him, he immediately recognized a spelling error in it. In addition, hand-eye coordination was also relearned within a few hours. The patients were able to localize physical objects precisely and point to them immediately.
Geometric patterns and physical objects from daily life were recognized, especially when they had very characteristic forms (such as a banana). They were also able to distinguish items of tableware (spoons, knives, forks) from one another.
Now that the pilot study is complete, the implant has become the subject of a multicentered main study with a larger patient set. The aim of the investigation is to gain regulatory approval for use as a medical product in 1-2 years. After it has been successfully used in retinitis pigmentosa patients, the plan is to test and apply the visual chip in patients with age-related macula degeneration (AMD) as well.

Acknowledgements

This research was supported by the German Federal Ministry of Education and Research, the Kerstan Foundation, and ProRetina Germany.
References
  1. E Zrenner, “Will Retinal Implants Restore Vision?” Science 295, no. 5597 (February 2002): 1022–1025.
  2. HG Graf et al., “High Dynamic Range CMOS Imager Technologies for Biomedical Applications,” IEEE Journal of Solid-State Circuits 44, no. 1 (January 2009):  281–289.
  3. E Zrenner, “Restoring Neuroretinal Function: New Potentials, Documenta Ophthalmologica (2007): 56–59.
  4. E Zrenner et al., “Subretinal Electronic Chips Allow Blind Patients to Read Letters and Combine Them to Words,” Proceddings of the Royal Society, Biological Sciences, online (November 3, 2010): doi:10.1098/rspb.2010.1747.
  5. L Rothermel et al., “A CMOS Chip With Active Pixel Array and Specific Test Features for Subretinal Implantation” IEEE Journal of Solid-State Circuits 44, no. 1 (January 2009): 290–300.
Walter-G. Wrobel, PhD, is president and CEO of Retina Implant AG. Alex Harscher, PhD, is vice president of operations at the company.